The term “nodding off” or “nodding out on drugs” describes a state where a person drifts in and out of consciousness. This behavior often happens with certain substances. Opioids and benzodiazepines are the most common, but other drugs can also cause it.

While it might seem harmless at first, frequent nodding off can be a dangerous sign of drug misuse or overdose.

What Does “Nodding Off” or “Nodding Out on Drugs” Mean?

“Nodding off” or “nodding out” describes a state where a person is half awake and half asleep. In this state, the person may look sleepy or close to falling asleep. They might still be aware of their surroundings and can respond to stimuli, but their alertness is much lower. They may have trouble staying fully awake or engaged with their surroundings.

This behavior is commonly associated with the use of opioids (such as heroin, prescription painkillers, or fentanyl) and benzodiazepines (like Xanax or Valium), both of which have sedative effects on the central nervous system. 

While nodding off may appear harmless, it can be a dangerous sign of drug misuse or even overdose. In many cases, the drug makes it hard for the body to stay awake and alert.

Nodding off or nodding out happens when someone takes too much of a substance. This can be very dangerous. It may cause serious problems like trouble breathing or passing out.

Common Drugs That Cause Nodding Off

Several substances can cause individuals to “nod off” or drift into a state of extreme drowsiness. These drugs typically have depressant effects on the central nervous system, slowing brain activity and bodily functions, which leads to sedation and sleepiness.

Here are some of the most common drugs associated with nodding off:

Opioids (e.g., Heroin, Prescription Painkillers)

Opioids are common drugs that can make people fall asleep. This group includes heroin, morphine, and prescription painkillers like oxycodone and hydrocodone.

Opioids attach to opioid receptors found in the brain, which helps to block pain and induce feelings of euphoria.

However, they also significantly slow down brain function and breathing. This sedative effect can cause drowsiness and confusion. In some cases, a person may drift in and out of consciousness, leading to “nodding off.”

The more opioids a person consumes, the greater the risk of overdose, which can result in life-threatening respiratory depression.

Benzodiazepines (e.g., Xanax, Valium)

Benzodiazepines, such as Xanax, Valium, and Ativan, are commonly prescribed for anxiety, panic disorders, and insomnia.

These sedative medications help by boosting the effects of GABA, a neurotransmitter that slows down brain activity. This leads to a calming and relaxing effect.

While this makes benzodiazepines effective for managing anxiety, they can also cause drowsiness and induce the state of “nodding off.”

If taken in high doses or mixed with other drugs, benzodiazepines can cause strong sedation. They can also harm memory and raise the risk of overdose.

Other Substances (Alcohol, Barbiturates)

Alcohol and barbiturates (another class of central nervous system depressants) can also contribute to nodding off.

Alcohol makes you feel relaxed and can cause drowsiness. If you drink a lot, it may even make you unconscious.

Similarly, barbiturates, which were once commonly prescribed for anxiety and sleep disorders, have similar depressant effects. They slow brain activity and can lead to sedation, lethargy, and the inability to stay fully awake.

Both alcohol and barbiturates can increase the risk of overdose. This risk is even higher when they are taken with other depressants, like opioids or benzodiazepines. Serious health problems can also occur.

Why Does Nodding Off Happen? The Science Behind It

Nodding off occurs when the brain and nervous system are affected by certain drugs, particularly opioids and benzodiazepines.

These substances slow down the central nervous system (CNS), leading to drowsiness, sedation, and, in some cases, unconsciousness.

To understand why this happens, it’s important to look at how these drugs interact with the brain’s neurotransmitters and alter brain chemistry.

Impact on Neurotransmitters

Drugs like opioids (e.g., heroin, prescription painkillers) and benzodiazepines (e.g., Xanax, Valium) primarily affect neurotransmitters. Neurotransmitters are chemicals that transmit signals between nerve cells in the brain.

Here’s how they interact with specific neurotransmitters:

  • Opioids, in particular, increase dopamine levels in the brain. This neurotransmitter is often called the “feel-good” chemical because of its key role in pleasure and reward. The surge in dopamine levels produced by opioids causes feelings of euphoria, but it also depresses the brain’s ability to sustain normal levels of alertness and function, leading to drowsiness.
  • Many benzodiazepines affect serotonin levels, which regulate mood, anxiety, and sleep. When drugs alter serotonin, it can cause a relaxing or sedative effect that leads to drowsiness and an altered state of consciousness.
  • Benzodiazepines enhance or elevate the action of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that reduces brain activity. When GABA levels rise because of benzodiazepines, the central nervous system feels calm and relaxed, leading to a state of “nodding off.” This is also why benzodiazepines are effective for anxiety, but they can cause people to drift in and out of consciousness.

The Body’s Attempt to Balance Drug Levels

The body works to maintain balance in response to the chemicals introduced by drugs. When a person takes opioids or benzodiazepines, their brain and body first react by adjusting to these drugs.

Over time, the body may become dependent on the drug to function, leading to the need for more of the substance to achieve the desired effects.

As tolerance increases, the body finds it hard to stay alert. This can cause more drowsiness. It may even lead to nodding off, which shows that the drug levels have taken over the system.

Risks and Dangers of Nodding Out on Drugs

Nodding off may seem harmless at first, but it can signal serious risks. This is especially true for drugs that cause sedation, like opioids and benzodiazepines.

Overdose Risks

Nodding off is often an early warning sign that the body is becoming overwhelmed by the drug. It can indicate that the individual has ingested more of the substance than their body can handle. In many cases, this is a precursor to overdose.

When a person “nods out,” their body’s systems are slowing down to a dangerous extent, and without intervention, they may lose consciousness completely or enter a coma.

Overdose is especially likely if the individual has a history of substance use or mixes drugs, such as opioids with alcohol or benzodiazepines.

Respiratory Depression

One of the most serious risks of nodding off on drugs like opioids and benzodiazepines is respiratory depression. These substances depress the CNS, which can slow down vital functions such as heart rate and breathing. In severe cases, slowed breathing can be life-threatening.

When someone nods off, their breathing may become shallow and irregular. Left unchecked, this can lead to respiratory arrest, in which breathing stops altogether.

Cognitive and Physical Effects

Chronic misuse of sedative drugs can lead to memory problems, difficulty processing information, and long-term mental health issues.

Additionally, the physical consequences of regular nodding off include impaired motor skills, unsteady coordination, and sluggish reflexes.

What to Do If Someone Is Nodding Off on Drugs

If you notice someone nodding off or showing signs of an overdose, it’s crucial to take immediate action.

Here’s what you can do:

  • Immediate Action:
    • Stay with the person and try to keep them awake to help prevent further sedation.
    • Check for other signs of overdose, such as slow or irregular breathing, difficulty staying awake, or unconsciousness.
  • Call for Medical Help:
    • Call emergency services immediately (911 or the emergency number in your area) to get professional medical assistance. Be sure to mention the drugs involved so emergency responders can prepare for the situation.
    • In the case of opioids, if available, naloxone (Narcan) can be used to reverse an opioid overdose, but emergency medical care is still needed.
  • Seeking Help for Addiction:
    • If the individual is struggling with addiction, professional treatment is necessary. Treatment centers like Archstone Behavioral Health provide specialized programs to address substance use disorder and help individuals regain control over their lives.
    • A treatment program typically includes medically supervised detox, counseling, and aftercare services to help individuals safely manage withdrawal, understand the root causes of their addiction, and develop healthier, better-coping mechanisms.

At Archstone Behavioral Health, we are dedicated to helping people who struggle with drug misuse. This includes those who show risky behaviors, like nodding off.

With complete addiction treatment programs, we can help people escape the cycle of dependence. We also help them build the tools they need for lasting recovery.

If you or someone you know is struggling, don’t wait—contact us today to take the first step toward healing.

References:

  1. National Cancer Institute: central nervous system depressant
  2. Science Direct: Central Depressant Agent

The term “nodding off” or “nodding out on drugs” describes a state where a person drifts in and out of consciousness. This behavior often happens with certain substances. Opioids and benzodiazepines are the most common, but other drugs can also cause it.

While it might seem harmless at first, frequent nodding off can be a dangerous sign of drug misuse or overdose.

What Does “Nodding Off” or “Nodding Out on Drugs” Mean?

“Nodding off” or “nodding out” describes a state where a person is half awake and half asleep. In this state, the person may look sleepy or close to falling asleep. They might still be aware of their surroundings and can respond to stimuli, but their alertness is much lower. They may have trouble staying fully awake or engaged with their surroundings.

This behavior is commonly associated with the use of opioids (such as heroin, prescription painkillers, or fentanyl) and benzodiazepines (like Xanax or Valium), both of which have sedative effects on the central nervous system. 

While nodding off may appear harmless, it can be a dangerous sign of drug misuse or even overdose. In many cases, the drug makes it hard for the body to stay awake and alert.

Nodding off or nodding out happens when someone takes too much of a substance. This can be very dangerous. It may cause serious problems like trouble breathing or passing out.

Common Drugs That Cause Nodding Off

Several substances can cause individuals to “nod off” or drift into a state of extreme drowsiness. These drugs typically have depressant effects on the central nervous system, slowing brain activity and bodily functions, which leads to sedation and sleepiness.

Here are some of the most common drugs associated with nodding off:

Opioids (e.g., Heroin, Prescription Painkillers)

Opioids are common drugs that can make people fall asleep. This group includes heroin, morphine, and prescription painkillers like oxycodone and hydrocodone.

Opioids attach to opioid receptors found in the brain, which helps to block pain and induce feelings of euphoria.

However, they also significantly slow down brain function and breathing. This sedative effect can cause drowsiness and confusion. In some cases, a person may drift in and out of consciousness, leading to “nodding off.”

The more opioids a person consumes, the greater the risk of overdose, which can result in life-threatening respiratory depression.

Benzodiazepines (e.g., Xanax, Valium)

Benzodiazepines, such as Xanax, Valium, and Ativan, are commonly prescribed for anxiety, panic disorders, and insomnia.

These sedative medications help by boosting the effects of GABA, a neurotransmitter that slows down brain activity. This leads to a calming and relaxing effect.

While this makes benzodiazepines effective for managing anxiety, they can also cause drowsiness and induce the state of “nodding off.”

If taken in high doses or mixed with other drugs, benzodiazepines can cause strong sedation. They can also harm memory and raise the risk of overdose.

Other Substances (Alcohol, Barbiturates)

Alcohol and barbiturates (another class of central nervous system depressants) can also contribute to nodding off.

Alcohol makes you feel relaxed and can cause drowsiness. If you drink a lot, it may even make you unconscious.

Similarly, barbiturates, which were once commonly prescribed for anxiety and sleep disorders, have similar depressant effects. They slow brain activity and can lead to sedation, lethargy, and the inability to stay fully awake.

Both alcohol and barbiturates can increase the risk of overdose. This risk is even higher when they are taken with other depressants, like opioids or benzodiazepines. Serious health problems can also occur.

Why Does Nodding Off Happen? The Science Behind It

Nodding off occurs when the brain and nervous system are affected by certain drugs, particularly opioids and benzodiazepines.

These substances slow down the central nervous system (CNS), leading to drowsiness, sedation, and, in some cases, unconsciousness.

To understand why this happens, it’s important to look at how these drugs interact with the brain’s neurotransmitters and alter brain chemistry.

Impact on Neurotransmitters

Drugs like opioids (e.g., heroin, prescription painkillers) and benzodiazepines (e.g., Xanax, Valium) primarily affect neurotransmitters. Neurotransmitters are chemicals that transmit signals between nerve cells in the brain.

Here’s how they interact with specific neurotransmitters:

  • Opioids, in particular, increase dopamine levels in the brain. This neurotransmitter is often called the “feel-good” chemical because of its key role in pleasure and reward. The surge in dopamine levels produced by opioids causes feelings of euphoria, but it also depresses the brain’s ability to sustain normal levels of alertness and function, leading to drowsiness.
  • Many benzodiazepines affect serotonin levels, which regulate mood, anxiety, and sleep. When drugs alter serotonin, it can cause a relaxing or sedative effect that leads to drowsiness and an altered state of consciousness.
  • Benzodiazepines enhance or elevate the action of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that reduces brain activity. When GABA levels rise because of benzodiazepines, the central nervous system feels calm and relaxed, leading to a state of “nodding off.” This is also why benzodiazepines are effective for anxiety, but they can cause people to drift in and out of consciousness.

The Body’s Attempt to Balance Drug Levels

The body works to maintain balance in response to the chemicals introduced by drugs. When a person takes opioids or benzodiazepines, their brain and body first react by adjusting to these drugs.

Over time, the body may become dependent on the drug to function, leading to the need for more of the substance to achieve the desired effects.

As tolerance increases, the body finds it hard to stay alert. This can cause more drowsiness. It may even lead to nodding off, which shows that the drug levels have taken over the system.

Risks and Dangers of Nodding Out on Drugs

Nodding off may seem harmless at first, but it can signal serious risks. This is especially true for drugs that cause sedation, like opioids and benzodiazepines.

Overdose Risks

Nodding off is often an early warning sign that the body is becoming overwhelmed by the drug. It can indicate that the individual has ingested more of the substance than their body can handle. In many cases, this is a precursor to overdose.

When a person “nods out,” their body’s systems are slowing down to a dangerous extent, and without intervention, they may lose consciousness completely or enter a coma.

Overdose is especially likely if the individual has a history of substance use or mixes drugs, such as opioids with alcohol or benzodiazepines.

Respiratory Depression

One of the most serious risks of nodding off on drugs like opioids and benzodiazepines is respiratory depression. These substances depress the CNS, which can slow down vital functions such as heart rate and breathing. In severe cases, slowed breathing can be life-threatening.

When someone nods off, their breathing may become shallow and irregular. Left unchecked, this can lead to respiratory arrest, in which breathing stops altogether.

Cognitive and Physical Effects

Chronic misuse of sedative drugs can lead to memory problems, difficulty processing information, and long-term mental health issues.

Additionally, the physical consequences of regular nodding off include impaired motor skills, unsteady coordination, and sluggish reflexes.

What to Do If Someone Is Nodding Off on Drugs

If you notice someone nodding off or showing signs of an overdose, it’s crucial to take immediate action.

Here’s what you can do:

  • Immediate Action:
    • Stay with the person and try to keep them awake to help prevent further sedation.
    • Check for other signs of overdose, such as slow or irregular breathing, difficulty staying awake, or unconsciousness.
  • Call for Medical Help:
    • Call emergency services immediately (911 or the emergency number in your area) to get professional medical assistance. Be sure to mention the drugs involved so emergency responders can prepare for the situation.
    • In the case of opioids, if available, naloxone (Narcan) can be used to reverse an opioid overdose, but emergency medical care is still needed.
  • Seeking Help for Addiction:
    • If the individual is struggling with addiction, professional treatment is necessary. Treatment centers like Archstone Behavioral Health provide specialized programs to address substance use disorder and help individuals regain control over their lives.
    • A treatment program typically includes medically supervised detox, counseling, and aftercare services to help individuals safely manage withdrawal, understand the root causes of their addiction, and develop healthier, better-coping mechanisms.

At Archstone Behavioral Health, we are dedicated to helping people who struggle with drug misuse. This includes those who show risky behaviors, like nodding off.

With complete addiction treatment programs, we can help people escape the cycle of dependence. We also help them build the tools they need for lasting recovery.

If you or someone you know is struggling, don’t wait—contact us today to take the first step toward healing.

References:

  1. National Cancer Institute: central nervous system depressant
  2. Science Direct: Central Depressant Agent

Medically Reviewed: January 9, 2025

Medical Reviewer

Chief Editor

medically-verified

All of the information on this page has been reviewed and verified by a certified addiction professional.